Product Code Database
The stratum spinosum (or spinous layer/prickle cell layer) (2025). 9780632064298, Blackwell Science. ISBN 9780632064298 is a layer of the epidermis found between the stratum granulosum and stratum basale. (2025). 9780721629216, Saunders Elsevier. ISBN 9780721629216 This layer is composed of polyhedral . These are joined with . Their spiny (Latin, spinosum) appearance is due to shrinking of the between desmosomes that occurs when stained with H&E. Keratinization begins in the stratum spinosum, (2025). 9781416031857, Saunders Elsevier. ISBN 9781416031857 although the actual keratinocytes begin in the stratum basale. They have large pale-staining nuclei as they are active in synthesizing fibrillar proteins, known as cytokeratin, which build up within the cells aggregating together forming tonofibrils. The tonofibrils go on to form the desmosomes, which allow for strong connections to form between adjacent keratinocytes. The stratum spinosum also contains , which functions as a macrophage by engulfing bacteria, foreign particles, and damaged cells that occur in this layer. (2025). 9780443056123, Churchill Livingstone. ISBN 9780443056123 (2025). 9780080921525 ISBN 9780080921525 (2023). 9781947172043, OpenStax CNX. ISBN 9781947172043
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